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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can reduce panobinostat levels by ~70% and bring about therapy failure.Keep track of Closely (one)pentobarbital will lessen the extent or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4